The objective of our molecular microbiology laboratory is to understand the mechanisms associated with the metabolism of essential metals by multidisciplinary approaches. We combine in vivo, in vitro and in silico studies, from the bacterial cell (mainly photosynthetic, magnetotactic or radioresistant) to purified proteins. Our work focuses on the mechanisms of (i) metal acquisition and insertion in metalloproteins, (ii) metal sequestration and biomineralization in a dedicated procaryotic organelle (magnetosome) and (iii) ) response to oxidative stress (and radiative) associated. This fundamental approach underpins developments in the areas of environmental and health biotechnology.
Contact: Dr. Christopher Lefevre, Saint Paul-lez-Durance, France