The two years aim of this cluster is to create a strong, multidisciplinary consortium that can successfully apply for a long term convergence research project on TDD. Our strategy is based on three parallel lines:
1. Exchange of ideas and experiences
Two intensive workshops will be organised. During the workshop, the partners will present their skills, former results and ideas. The first workshop is being considered to be combined with the MTB2018 conference in september 2018. The MTB conference is dedicated only to magneto-tactic bacteria, and is attended by all major research groups in this field. A small selection of experts attending the conference will be invited to join the workshop and advise the participants. The second workshop will be organized in the summer of 2019. The main topic of this workshop will be the preparation for the follow-up proposal.
2. Exchange of know-how and expertise
Detailed know-how on experimental procedures will be transferred by means of on-site visits of PhD students or postdocs for a period of one to six weeks. Where required, national or Euroepan funds will be applied for to enable the exchange of personnel. During the visits, laboratory procedures will be exchanged.
3. Exchange of samples and analytical instrumentation
The interaction between the partners will be intensified by using a common experimental platform. For this, we will organise an air-bridge to transfer micro-organisms and materials between Korea and Europe
Main aim: Magnetic nanoparticles for drug delivery produced by magneto-tactic bacteria
With WP1 we study how we can increase the magneto-some crystal production by MTB cultures, and how these crystal can be used for targeted drug delivery.
Active partners
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Korea Univ.: Analysis of magneto-some crystals (Leading partner)
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Magron: Upscaling of magneto-some crystal production
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KIST: Targeted drug delivery using magnetosome crystals
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KBSI: High resolution analysis of magnetosome crystals
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Nanobacterie: Optimisation of magneto-some crystal production
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CNRS: Cultivation and separation of magneto-some crystals
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NanoPET: Application of nanoparticles as imaging agents
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KIST Europe: Culture optimisation and instrumentation for MTB analysis
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MPI: Optimisation of magneto-some formation
Main aim: Drug delivery using magneto-tactic bacteria
With WP2 we study how we can apply MTB as magnetically steerable carriers for targeted drug delivery.
Active partners
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Chonnam Medical School: Investigation of the optimum therapeutic loading methodology for MTB (Leading partner)
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Seoul National University: MTB Cultivation and drug delivery
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HIPS: MTB based drug delivery through biological barriers
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KIST Europe: Nanomagnetic optimisation of MTB in controlled microfluidic environments
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Aston University: High volume production of MTB
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Yonsei University: Mechanostimulation of cells
Main aim: Targeted drug delivery using magnetic nanorobots as carriers
With WP3 we study how we can learn from magneto-tactic bacteria models of magnetically steerable carriers for targeted drug delivery.
Active partners
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DGIST: Fabrication of scaffold nanorobots, imaging of nanorobots and MTB (Leading partner)
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KIMM: Large scale fabrication of nanorobots
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ETH: Fabrication and control of nanorobots and MTB
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KIST Europe: Control of nanorobots and MTB in microfluidic environments
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